A randomized controlled trial of the therapeutic workplace for community methadone patients: A partial failure to engage.

The Therapeutic Workplace is an employment-based treatment for drug addiction that uses wages for work to reinforce drug abstinence. The Therapeutic Workplace has promoted abstinence from heroin and cocaine in treatment-resistant mothers in methadone treatment. This study attempted to replicate that effect in crack cocaine users recruited from community-based methadone programs. Participants were randomly assigned to a Therapeutic Workplace (n=22) or usual care control (n=25) group. Therapeutic Workplace participants were invited to work in the workplace and earn vouchers every weekday for 9 months contingent on documented opiate and cocaine abstinence. The two groups did not differ significantly on measures of cocaine or opiate use collected during study participation. Daily attendance and urinalysis results of the Therapeutic Workplace group were analyzed, and only 7 of the 22 participants initiated consistent periods of abstinence and workplace attendance. Two individuals gained access to the workplace on a few days, and 9 participants attempted to gain access to the workplace but never provided a drug-negative urine sample. Possible reasons for differences between the current study and the previous Therapeutic Workplace study are considered. Procedures that increase participant contact with the Therapeutic Workplace and its reinforcement contingencies might increase the likelihood of these individuals being successful in the treatment program. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Reliability and validity of the Parent-Child Relationship Inventory (PCRI): Evidence from a longitudinal cross-informant investigation.

Psychometric properties of the Parent-Child Relationship Inventory (PCRI) were examined using data collected from adolescents and their parents in the Fullerton Longitudinal Study. Results revealed acceptable internal consistency for most scales and moderate to high 1-year stability for all scales. Both parents' PCRI scores correlated with their views of family climate. Cross-informant concordance was pervasive and strong between mothers' PCRI scores and adolescents' perceptions of the parent-child relationship and family climate; however, convergence was not evident between fathers' and adolescents' reports. Additionally, poor performance was observed for the Autonomy scale. In conjunction with other research on parent-adolescent relationships, concerns are raised regarding the utility of scales to contrast mother-adolescent with father-adolescent relationships. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Strategies for handling treatment failure successfully.

This article addresses the topic of treatment failure in psychotherapy. The authors argue that treatment failure is common, that it is rarely discussed, and that clinicians do not manage it effectively. They elaborate on a well-established hypothesis-testing model of clinical work to provide an algorithm that includes strategies clinicians can use to prevent, identify, overcome, and accept treatment failure. They illustrate the use of the algorithm to guide the initially failing treatment of a hypochondriacal attorney. They conclude with a discussion of obstacles to using the algorithm. The algorithm is largely orientation neutral, but cognitive-behavior therapists are likely to find it most compatible with their theoretical model. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Development of beliefs about the origins and controllability of dreams.

In three studies the authors investigated the development of beliefs about dreaming. Study 1 assessed 3 to 5-year-old children's beliefs about the origins and controllability of dreams. Results revealed significant changes in children's beliefs about the roles of behavioral experiences and mental processes in the generation of dream content. Results also revealed that young children consider both dreams and imagination to be highly controllable. In Study 2, preschool-age children, elementary school-age children, and adults received either imagination or dream stories and were questioned about controllability. In Study 3, emotional valence of the dream content was varied. Results of Studies 2 and 3 revealed significant development in beliefs that dreams are not subject to conscious control. Beliefs in controllability were higher among females. Study 3 showed that the emotional content of a dream affects these claims. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Economic Comparison of NdFeB and Hard Ferrites in Automotive Applications

With the increasing use of electric motors in automobiles—in some cases as many as 100 electric motors per vehicle—alternatives to ferrite magnetic materials are under consideration. If more powerful magnetic materials could be implemented, size reductions in these motors could result in curb weight reductions that lead to improved fuel economy. NdFeB magnets are attractive as potential replacement materials, due to their higher flux density and thus smaller required size; however, high material costs have limited their implementation. To investigate the economic competitiveness of alternative magnetic materials, technical cost models (TCMs) were developed and used to examine the manufacturing economics related to the production of both NdFeB and ferrite magnets. Results from the TCMs are used to identify the cost drivers and opportunities for cost reductions. Subsequent investigations will include effects on vehicle fuel efficiency, and the environmental impact of magnet manufacture and disposal.     

Social competence promotion with inner-city and suburban young adolescents: Effects on social adjustment and alcohol use.

Assessed the impact of school-based social competence training on skills, social adjustment, and self-reported substance use of 282 6th and 7th graders. Training emphasized broad-based competence promotion in conjunction with domain-specific application to substance abuse prevention. The 20-session program comprised 6 units: stress management, self-esteem, problem solving, substances and health information, assertiveness, and social networks. Findings indicated positive training effects on Ss' skills in handling interpersonal problems and coping with anxiety. Teacher ratings revealed improvements in Ss' constructive conflict resolution with peers, impulse control, and popularity. Self-report ratings indicated gains in problem-solving efficacy. Results suggest some preventive impact on self-reported substance use intentions and excessive alcohol use. In general, the program was found to be beneficial for both inner-city and suburban students. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

SMOS first data analysis for sea surface salinity determination

Soil Moisture and Ocean Salinity (SMOS), launched on 2 November 2009, is the first satellite mission addressing sea surface salinity (SSS) measurement from space. Its unique payload is the Microwave Imaging Radiometer using Aperture Synthesis (MIRAS), a new two-dimensional interferometer designed by the European Space Agency (ESA) and operating at the L-band frequency. This article presents a summary of SSS retrieval from SMOS observations and shows initial results obtained one year after launch. These results are encouraging, but also indicate that further improvements at various data processing levels are needed and hence are currently under investigation.     

The Multifunctional Sactipeptide Ruminococcin C1 Displays Potent Antibacterial Activity In Vivo as Well as Other Beneficial Properties for Human Health

The world is on the verge of a major antibiotic crisis as the emergence of resistant bacteria is increasing, and very few novel molecules have been discovered since the 1960s. In this context, scientists have been exploring alternatives to conventional antibiotics, such as ribosomally synthesized and post-translationally modified peptides (RiPPs). Interestingly, the highly potent in vitro antibacterial activity and safety of ruminococcin C1, a recently discovered RiPP belonging to the sactipeptide subclass, has been demonstrated. The present results show that ruminococcin C1 is efficient at curing infection and at protecting challenged mice from Clostridium perfringens with a lower dose than the conventional antibiotic vancomycin. Moreover, antimicrobial peptide (AMP) is also effective against this pathogen in the complex microbial community of the gut environment, with a selective impact on a few bacterial genera, while maintaining a global homeostasis of the microbiome. In addition, ruminococcin C1 exhibits other biological activities that could be beneficial for human health, as well as other fields of applications. Overall, this study, by using an in vivo infection approach, confirms the antimicrobial clinical potential and highlights the multiple functional properties of ruminococcin C1, thus extending its therapeutic interest.     

Molecular Mechanisms Underlying the Beneficial Effects of Exercise on Brain Function and Neurological Disorders

As life expectancy has increased, particularly in developed countries, due to medical advances and increased prosperity, age-related neurological diseases and mental health disorders have become more prevalent health issues, reducing the well-being and quality of life of sufferers and their families. In recent decades, due to reduced work-related levels of physical activity, and key research insights, prescribing adequate exercise has become an innovative strategy to prevent or delay the onset of these pathologies and has been demonstrated to have therapeutic benefits when used as a sole or combination treatment. Recent evidence suggests that the beneficial effects of exercise on the brain are related to several underlying mechanisms related to muscle–brain, liver–brain and gut–brain crosstalk. Therefore, this review aims to summarize the most relevant current knowledge of the impact of exercise on mood disorders and neurodegenerative diseases, and to highlight the established and potential underlying mechanisms involved in exercise–brain communication and their benefits for physiology and brain function.